Benzodiazepines: Uses, Side Effects, and Long-Term Risks

Beware of online pharmacy purchases; in general, consumers in the U.S. should only purchase medications from their local pharmacy or a health-plan administered mail-order pharmacy. As noted in the Boxed Warnings, concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Withdrawal reactions can also occur if the drug is stopped suddenly, especially those that are shorter-acting. Discontinuation of a benzodiazepine should be done gradually under a doctor’s direction.

Medical Usesedit edit source

These drugs treat a range of mental and physical health conditions, including anxiety, seizures, and panic attacks. These prescription drugs are usually effective and safe when used for a short time. Benzodiazepines and beta-blockers are useful as needed to reduce severe anxiety in the short-term. However, taking benzodiazepines over long periods may lead to drug tolerance or even dependence. To avoid these problems, health care providers usually prescribe benzodiazepines for short periods and taper them slowly to reduce the likelihood of withdrawal symptoms or renewed anxiety symptoms.

SNRIs might work better in some people if SSRIs haven’t brought improvement. According to the National Institute of Mental Health (NIMH), nearly 57.8 million adults 18 and older reported a mental health condition in 2021. Psychotropic is an umbrella term for a lot of different drugs, including prescription and recreational drugs.

What are mental health medications?

Many traditional benzodiazepines are broken down in the liver and when combined with drugs that block this action, blood levels can rise, leading to side effects. Lorazepam, oxazepam and temazepam are less likely to have this risk due to fewer liver enzyme interactions. Sudden discontinuation can also lead to rebound insomnia, making sleep difficult and leading to continued use and higher doses of benzodiazepines, a dangerous cycle. Clonazepam is the benzodiazepine most frequently used for long-term control and prevention of chronic seizure disorders; however, in general benzodiazepines are not usually the first choice for seizure prevention. All benzodiazepines are listed as DEA schedule IV controlled substances.

  • Benzodiazepines treat anxiety, insomnia, seizures, muscle spasms, and alcohol withdrawal by calming the central nervous system and reducing overactivity.
  • Saxenda (liraglutide) injection is used for weight loss in obese or overweight patients.
  • Midazolam, in particular, is one of the most lipophilic benzodiazepines, meaning it rapidly crosses the blood-brain barrier (to enter your CNS).
  • Cognitive behavioral therapy has demonstrated its effectiveness in the research.

Long-term use is defined as two or more months at a therapeutic dose and when used long-term, BZDs pose potential harmful effects. Some additional side effects of concern include aggressive behavior and expressing anger towards others in between 1% and 20% of users 17. The main driving factor for dependence is the development of tolerance, causing users to need increasing doses for the same symptom relief 18. Benzodiazepines are commonly prescribed drugs in outpatient and hospitalized patients. Benzodiazepines are effective for sedation and anxiolysis; they also have the potential to cause harm.

  • Each of these studies received mixed results, with no statistically significant advantage to BZD therapy.
  • This duration of tapering is linked to long-term abstinence from benzodiazepines.
  • In comparison, Klonopin (clonazepam) is taken by mouth and used more often for panic disorder and seizure prevention because it lasts longer and is usually taken two times per day.
  • They found significant changes in sleep microstructure in chronic insomnia with high dosage abuse of BZD, but sleep architecture changes were not significant.

Alcohol withdrawal

list of common benzodiazepines + uses and side effects

These medications can also cause dependence and lead to substance use disorders. Psychotropic drugs have many interactions with other drugs, food, alcohol, and over-the-counter (OTC) products. Always tell your doctor and pharmacist all the medications and supplements you’re taking to help prevent adverse reactions. This is one of the oldest classes of antidepressants still available on the market. Aripiprazole (Abilify), clozapine (Clozaril), and quetiapine (Seroquel) have a black box warning for specific safety concerns.

Benzodiazepine Tolerance and Withdrawal

Starting in October 2024, over 200,000 bottles of duloxetine delayed-release capsules were recalled over concerns about the presence of nitrosamines, which can increase the risk of cancer. If you take duloxetine, check your medication packaging to see if it was part of the affected lots or call your pharmacist to find out. You should also contact your prescriber, as abruptly stopping a medication like duloxetine can be dangerous. Examples of commonly prescribed SSRis include Prozac (fluoxetine) and Lexapro (escitalopram). Venlafaxine is used to treat major depressive disorder, anxiety, and panic disorder. Overdose symptoms may include severe drowsiness, confusion, slurred speech, muscle weakness, loss of balance or coordination, feeling light-headed, slow heartbeats, weak or shallow breathing, fainting, or coma.

This is supported in a similar study of elderly adults on a BZD for six months with drug discontinuation one month later. The study found no significant cognitive impairment in adults with long-term use of BZD 20. A study of over 2000 older adults assessed the effects of chronic BZD use on cognition 21. Chronic use of BZD leads to a small but significant change in fluid intelligence, while long-term use of BZD correlates with worse cognitive decline when compared to the effects of using a high dosage 21. Mood stabilizers are sometimes used to treat depression (usually along with an antidepressant), schizoaffective disorder, disorders of impulse control, and certain mental illnesses in children.

It’s illegal to have or obtain them (depending on the laws where you are) if you don’t have a prescription. All benzodiazepines work in a similar way but there are differences in the way individual benzodiazepines act on different GABA-A receptor sub-types. In addition, some benzodiazepines are more potent than others or work for a longer length of time. The table below summarizes the common benzodiazepines available in the U.S.

Related treatment guides

These 5 subunits include 2 alpha subunits, 2 beta subunits, and 1 gamma subunit. The extracellular portions of the alpha and beta subunit proteins form a receptor site for GABA, which is an inhibitory neurotransmitter. The extracellular portions of the alpha and gamma subunit proteins form a binding site for benzodiazepines. These effects help relieve the symptoms of certain conditions it’s used for, such as anxiety and panic disorder, and are why it is sometimes used for sedation. NIMH does not provide medical advice, endorse or recommend specific medications, or offer treatment referrals. If a person’s symptoms do not improve with usual antipsychotic medications, they may be prescribed an atypical antipsychotic called clozapine .

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Some parents worry that stimulants may lead to misuse or dependence, but evidence shows this is unlikely when the medications are used as prescribed. Other challenges with stimulant treatment, such as sleep disturbance and slowed growth, can generally be safely managed by a health care provider. In a 12-month period spanning 2014 and 2015, experts estimate that at least 30.5 million people in the U.S. took benzodiazepines prescribed by a healthcare provider. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

People should not stop taking a prescribed medication, even if they are feeling better, without the help of a health care provider. A provider can adjust the treatment plan to slowly and safely decrease the medication dose. Stopping a medication too soon may cause unpleasant or harmful side effects. Lithium , an effective mood stabilizer, is approved for the treatment of mania and bipolar disorder. Some studies indicate that lithium may reduce the risk of suicide among people taking it for long-term symptom maintenance. Health care providers generally ask people who are taking lithium to participate in regular monitoring to check lithium levels and kidney and thyroid function.

Certain factors play a role in the severity of withdrawal symptoms, such as dosage, duration of action of the BZD duration of treatment with the drug, and severity of psychiatric symptoms pre-treatment. Studies have shown that treatment for longer periods with high-dosage, short-acting BZD contribute to more severe withdrawal effects 61. Milder effects are seen with longer-acting BZD that are used for shorter periods 61. Those who have never experienced withdrawal symptoms from BZD discontinuation could quit using BZD more easily 62. People with severe anxiety before starting treatment with BZD typically have more severe withdrawal symptoms, and thus have a list of common benzodiazepines + uses and side effects harder time fully discontinuing the drug 63. Psychiatric diagnoses have also been linked to one’s ability to discontinue treatment with BZD.

Beware of online pharmacy purchases; in general, consumers in the U.S. should only purchase medications from their local pharmacy or…

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Bottles in the Basement: Surviving an Alcoholic A Memoir: McGloin, Paula Ganzi: 9798218281601: Amazon com: Books

In this post, best alcoholic memoirs we’ve put together nine of the best addiction memoirs and quit lit books for you to check out. From painfully honest stories to science-based tips, there’s a title on this list that’s sure to inspire and motivate you or someone in your life. This is a lesser known series of essays on the intersection of alcohol and womanhood.

  • Three years sober, Jowita Bydlowska celebrates the birth of her first child with a glass of champagne, and just like that, she is spiraling back into the life of drinking she thought she had escaped.
  • The book offers a poignant and raw portrayal of the impact of parental alcoholism on a young boy’s life, as well as the power of community and the search for identity.
  • Mitchell S. Jackson frames the narrative around his own experiences and those of his family and community.
  • Where the story they have to tell echoes others, they let us hear that echo.

by Mary Karr

  • Although opting for a diet fizzy drink will ensure you’re limiting your calorie intake, ideally save this as a one off if you’re craving something sweet and looking for variety.
  • I felt so much shame towards the end of my drinking and couldn’t talk to anyone about it.
  • This is more than a cookbook – it’s a captivating read and a gorgeous coffee table book to peruse over and over again.
  • It’s a memoir of her addiction to alcohol, and her subsequent recovery, and her conversion to Catholicism.

I mean help, whether in the form of identification, solace or instruction. I said this convention concerned reading more directly than writing, but—since all good writing involves deep sensitivity to the reader’s experience—the two things are ultimately inseparable. For one kind of author, helping the reader is the whole point of writing an addiction memoir; for another, even to consider doing so would be aesthetically fatal. My guess is that most addiction memoirs involve some kind of compromise between the author’s aesthetic and ethical impulses. This ethical dimension (or an aesthetic impurity) is a distinctive aspect of addiction memoir as a literary form. The Easy Way to Control Alcohol by Allen Carr is a revolutionary book about alcoholics that challenges traditional methods of dealing with alcohol addiction.

best alcoholic memoirs

Which Alcoholics book is best?

By addressing causes rather than symptoms, it is framed as a permanent solution rather than lifetime struggle. It removes the psychological dependence; allowing you to easily drink less (or stop drinking entirely). Sarah’s writing is sharp and relatable; a more recent, modern voice in the recovery space. So many of us look at “blacking out” as benign, or normal—an indicator of a “successful” night of drinking.

best alcoholic memoirs

Blackout: Remembering the Things I Drank to Forget by Sarah Hepola

It’s a relatively new genre of books helping people (particularly women) reassess their relationship with drinking. The books tend to be memoirs, written by those who’ve been through the process of giving up alcohol themselves, with some self-help guides and psychology-based books in there too. Educated by Tara Westover is a gripping memoir about a woman’s journey from a turbulent childhood in rural Idaho to earning a PhD from Cambridge University. Raised by survivalist parents with extreme beliefs, Tara https://thewebcube.com/the-difference-between-halfway-houses-and-sober/ Westover grew up isolated from society and without formal education. The book chronicles her struggle to break free from her family’s oppressive upbringing, including her father’s refusal to seek medical help for severe injuries and her mother’s skills as a midwife.

“Drinking: A Love Story” by Caroline Knapp

Prolific, brilliant memoirist Mary Karr shines a light on the dark years she spent descending into alcoholism and drug use as a young writer, wife, and mother. As her marriage dissolved and she struggled to find a reason to stay clean, Karr turned to Catholicism as a light at the end of the tunnel. A person of extraordinary intellect, Heather King is a lawyer and writer/commentator for NPR — as well as a recovering alcoholic who spent years descending from functional alcoholism to barely functioning at all.

Lit by Mary Karr

But the challenge is particularly acute when the story is about a life that, as the reader well knows, has simply gone on and on beyond the final page. Life doesn’t provide moments of satisfying narrative resolution. How do you craft an ending that makes narrative sense but which feels complex and inconclusive in the way life so often is?

The Unexpected Joy of Being Sober by Catherine Gray

Most are forgettable and forgotten, but some accomplished authors—like Caroline Knapp and Sarah Hepola—have created very good books by bringing real skill to the standard formula. In the literature world, you can find books about addiction and recovery in a genre known as “quit lit.” Quit lit is full of authors sharing their personal experiences and resources to help others who are where they’ve been. Reading a few chapters of a recovery-related book each day can help weave your sobriety or moderation goals into your everyday life. It can provide ongoing reminders of why you’re making a change, and give you new tools to incorporate as you continue on your journey.

The Daily Stoic: 366 Meditations on Wisdom, Perseverance and the Art of Living by Ryan Holiday

When you’ve got a six-year-old’s questions as your basis, there’s also some zingers. Grab the tissues and your pup before you crack open this book about a naughty dog who wriggled alcoholism symptoms Alcohol abuse his way into his owner’s heart. This book will take you through an emotional journey that will make you want to snuggle your own furry friend all the way through.

We Are the Luckiest is a life-changing memoir about recovery—without any sugarcoating. They encourage you to embrace the sober “Irish exit,” leaving the party early to enjoy a starlit stroll home. It includes recipes for zero-proof cocktails for all seasons and has tips for navigating the dating scene while completely sober.

In this post, best alcoholic memoirs we’ve put together nine of the best addiction memoirs and quit lit books for…

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